Research Paper Volume 12, Issue 22 pp 22892—22905

USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36

Figure 2. USP10 inhibition or deletion diminishes the formation of foam cell. (A, C) Cells were treated with Spautin-1 or USP10 siRNA and oxLDL (50 μg/ml) for the indicated time. Cell was stained with oil red o. The represent images were showed from three independent experiments. (B, D) The number of stained cells were counted. *p<0.05, **p<0.01 versus each vehicle control.