Research Paper Volume 12, Issue 22 pp 22892—22905

USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36

Figure 7. USP10-mediated lipid uptake depends on CD36 expression. (A) Macrophage was transfected with FLAG-USP10 plasmid with different doses for 48 h, followed by Dil-oxLDL for 6 h. (B) Macrophage was treated with Spautin-1 and /or FLAG-CD36 plasmid for 48 h. Dil-oxLDL was added for the additional 6 h. DAPI for cell nucleus. The images were taken by confocal microscopy.