Research Paper Volume 12, Issue 21 pp 21874—21889

Integrated analysis of transcriptomic and metabolomic data demonstrates the significant role of pyruvate carboxylase in the progression of ovarian cancer

class="figure-viewer-img"

Figure 5.

PPI analysis and miRNA regulatory networks. (A) PPI networks were constructed to visualize the relationships of differentially expressed genes screened from PC-knockdown samples compared to control samples. Red dots represent up-regulated genes and green dots refer to down-regulated genes. The points with a blue border refer to ovarian cancer-related genes. (B) miRNA regulatory network. A complex regulatory network was constructed to visualize connections of miRNAs, transcription factors, and genes related to ovarian cancer. The dots in red and green represent up- and down-regulated genes, respectively. Triangular nodes refer to miRNAs and v-shaped nodes represent transcription factors.