Research Paper Volume 12, Issue 20 pp 20728—20742

MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice


Figure 3. MiR-338-5p attenuated amyloid plaque deposition in APP/PS1 mice. (A, B) ELISA analysis of Aβ 40 (A) and Aβ 42 (B) level in APP/PS1 mice. Data are presented as ng Aβ 40 or Aβ 42 per ml total protein samples. (C, F) Thioflavin-S was used to stain the brain sections to show the number and area of amyloid plaques in hippocampus and cortex. Representative images of plaques in hippocampus and cortex aged 8-month-old (C) or 10-month-old (D). (E, F) Quantification analysis of the number (E) and area (F) of amyloid plaque. The plaques were shown with red fluorescence and cell nuclei were stained with blue fluorescence by DAPI. Scale bar=50 μm. Results are presented as mean ± SD. n = 6 in each group. *P < 0.05; **P<0.01.