Research Paper Volume 12, Issue 20 pp 20728—20742

MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice

Figure 4. MiR-338-5p retarded apoptotic loss of neurons in APP/PS1 mice. (A) The representative immunofluorescent images of TUNEL-positive neurons in 8-month-old WT and APP/PS1 mice. Green staining indicated TUNEL-positive cells and red staining indicated neurons. (B, C) Quantification of TUNEL-positive neurons in hippocampus (B) and cortex (C) of 8-month-old or 10-month-old WT and APP/PS1 mice. Scale bar=50 μm. Results are presented as mean ± SD. n = 5 in each group. **P < 0.01.