Research Paper Volume 12, Issue 21 pp 21890—21903

Comparative proteomic analysis identifies biomarkers for renal aging

Figure 1. Differentially expressed proteins (DEPs) in young and aged mouse kidneys. (A) Comparison of three proteomic datasets: this study and (14, 16). (B) Scatter plots showing correlations between our data to G-dataset (left) and to K-dataset (right) (Red dot, Peroxisome; Blue dot, Complement and coagulation cascades; Green dot, Retinol metabolism; Yellow dot, PPAR signaling pathway; Pink dot, Fatty acid degradation). (C) Determination of the cut-off thresholds for DEPs. (D) Volcano diagram of DEPs between aged and young mouse kidneys. (E, F) Venn diagram comparing the up-regulated (E) and down-regulated (F) proteins in this study and (14, 16). (G) Hierarchical clustering of DEPs presented in all three datasets.