Research Paper Volume 12, Issue 19 pp 19677—19700

Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation


Hormonal and microbiome changes in response to reduced mitochondrial protein synthesis in mice fed a normal and high fat diet. (A) Insulin, triglycerides, adiponectin, cholesterol, leptin, FGF21 and IL-6 levels were measured in serum obtained from 17-week-old Ptcd1+/+ (n=5) and Ptcd1+/- (n=5) mice after 12 weeks of HFD feeding. (B) The short chain fatty acids butyrate and acetate were measured in serum collected from Ptcd1+/+ (n=5) and Ptcd1+/- (n=5) mice. Error bars are SEM. *P < 0.05, **P<0.01, Student’s t test.