Risk of hospitalization from drug-drug interactions in the Elderly: real-world evidence in a large administrative database

Floor Swart; Giampaolo Bianchi; Jacopo Lenzi; Marica Iommi; Lorenzo Maestri; Emanuel Raschi; Marco Zoli; Fabrizio De Ponti; Elisabetta Poluzzi

doi:doi:10.18632/aging.104018

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Research Paper Volume 12, Issue 19 pp 19711—19739

Risk of hospitalization from drug-drug interactions in the Elderly: real-world evidence in a large administrative database

Forest plots of crude and adjusted odds ratios of hospitalization associated with current (last month) and past (≥2 months before) exposure to DDI, by interaction analysis. These odds ratios are unbiased estimates of the relative risk of hospitalization compared to no exposure to DDI, and are presented on the log scale. Note: Odds ratios are adjusted for covariates shown in Table 2. DDI, drug-drug interaction; CI, confidence interval; ACEIs, angiotensin converting enzyme inhibitors; ARBs, angiotensin II receptor blockers; SSRIs, selective serotonin reuptake inhibitors; NOACs, novel oral anticoagulants; NSAIDs, nonsteroidal anti-inflammatory drugs; ASA, acetylsalicylic acid.