COVID-19 Letter to the Editor Volume 12, Issue 21 pp 20938—20945

Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses

Figure 4. The evolutionary tree of 29 ACE2 gene sequences from different organisms. These ACE2 gene sequences from different hosts could be divided into 3 clades, with those that were closest to that of humans in evolution being from Nannospalax galili (Upper Galilee mountains blind mole rat), Phyllostomus discolor (pale spear-nosed bat), Mus musculus (house mouse), Delphinapterus leucas (beluga whale), and Catharus ustulatus (Swainson's thrush).