Research Paper Volume 12, Issue 22 pp 22975—23003

Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma

Figure 8. Schematic representation of the activation of AKT–ETS1–KIF14 positive feedback loop during acquired resistance to sorafenib in HCC. +, positive regulation or activation; −, negative regulation or blockade; p, regulation by phosphorylation. The solid line indicates direct interaction, whereas the dotted line indicates indirect interaction.