Research Paper Advance Articles pp 23822—23835

Calreticulin increases growth and progression of natural killer/T-cell lymphoma

Figure 1. High CALR expression correlates with shorter overall survival in patients with NKTCL. (A) CALR mRNA expression is upregulated in the NKTCL specimens compared to normal control tissues based on the GSE80632 dataset analysis (P < 0.05 according to Mann-Whitney U test). Note: The error bars represent standard error. (B) Representative images (400X magnification) show positive and negative immunohistochemical staining of CALR in the 26 NKTCL patient tissues and 10 reactive lymphoid hyperplasia patient tissues (controls). (C) Quantitative analysis based on immunohistochemical staining shows CALR protein levels in the 26 NKTCL and 10 reactive lymphoid hyperplasia patient samples. (D) Kaplan-Meier survival curve analysis shows the overall survival of NKTCL patients with high and low CALR expression. As shown, high CALR expression correlates with shorter overall survival in NKTCL patients.