Figure 7. SEMA4C overexpression correlates with the CMS4 subtype of CRC. (A) Box-scatter plot shows the SEMA4C mRNA level in CMS1, CMS2, CMS3 and CMS4 subtypes of CRC patient tissues in the TCGA dataset. (B) ROC curve analysis shows that SEMA4C expression levels accurately discriminate between CMS4 and non-CMS4 molecular subtypes of the TCGA-CRC dataset. Note: AUC: area under receiver operating characteristic, CI: confidence interval. (C, D) Kaplan-Meier survival curves show the OS in the high- and low- SEMA4C expressing (C) CMS1-3 and (D) CMS4 subgroups of TCGA-CRC patients. Log-rank test was used to determine the statistical differences between the groups.