Research Paper Advance Articles pp 23849—23871

Integrative analysis reveals novel driver genes and molecular subclasses of hepatocellular carcinoma

Figure 1. Identification and comparison of HCC drivers by integrative and single-platform approach. (A) Overview of the computational scheme for the systematic identification of drivers in HCC patients. Gray, red, green, purple, and orange represent mutations, copy number, DNA methylation, microRNA and mRNA, respectively. (B) Venn diagram and upset plot showing drivers recognized by different methods. (C) Regulation ability of drivers, measured by the number of modules. (D) Number of significantly enriched cancer hallmarks of driver genes.