Figure 4. Multi-omics integration to identify HCC subclasses. (A) COCA subclasses of HCC identified by integrating multiple-platform data. Each column represents a patient; grey color in the spectrum of somatic mutation means patients without exome sequencing data. (B) Kaplan–Meier estimates of overall survival among different patient subclasses. (C) Schematic summary of molecular and clinical characteristics of the four HCC subclasses.