Research Paper Volume 12, Issue 22 pp 23029—23046

ERRα inhibitor acts as a potential agonist of PPARγ to induce cell apoptosis and inhibit cell proliferation in endometrial cancer

Figure 4. PPARγ and ERRα compete to control cell proliferation and promote apoptosis in EC cells. (A) The effect of OV-PPARγ, OV-ERRα, GW9662 or XCT790 on proliferation. The OD values of HCE-1A and HEC-1B cells were detected at 0, 24, 48, 72, and 96 h after transfection with lentivirus or treatment with ERRα and PPARγ antagonists. (B, C) The effect of GW9662 or XCT790 on the cell cycle. HEC-1A and HEC-1B cells were treated with DMSO, GW9662 (5 μM) or XCT790 (10 μM) for 72 h. (D, E) The effect of OV-PPARγ or GW9662 on apoptosis.(F, G) The effect of OV-ERRα or XCT790 on apoptosis. OV-PPARγ: overexpression of PPARγ; OV-ERRα: overexpression of ERRα. EC, endometrial cancer. *, P<0.05; #, P>0.05.