Figure 4. PPARγ and ERRα compete to control cell proliferation and promote apoptosis in EC cells. (A) The effect of OV-PPARγ, OV-ERRα, GW9662 or XCT790 on proliferation. The OD values of HCE-1A and HEC-1B cells were detected at 0, 24, 48, 72, and 96 h after transfection with lentivirus or treatment with ERRα and PPARγ antagonists. (B, C) The effect of GW9662 or XCT790 on the cell cycle. HEC-1A and HEC-1B cells were treated with DMSO, GW9662 (5 μM) or XCT790 (10 μM) for 72 h. (D, E) The effect of OV-PPARγ or GW9662 on apoptosis.(F, G) The effect of OV-ERRα or XCT790 on apoptosis. OV-PPARγ: overexpression of PPARγ; OV-ERRα: overexpression of ERRα. EC, endometrial cancer. *, P<0.05; #, P>0.05.