Research Paper Advance Articles pp 23872—23888

Apigenin-7-O-β-D-(-6”-p-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation

Figure 5. Neuroprotective effect of APG treatment against focal cerebral ischemic/reperfusion injury in rats. (A) Neurological scores; (B) infarct volumes at 72 hours after reperfusion; (C) representative photographs of TTC staining. APG treatment significantly ameliorated the neurological scores and reduced infarct size compared with the I/R group (n = 8). * P < 0.05, ** P < 0.01. I/R = ischemia/reperfusion.