Research Paper Volume 12, Issue 21 pp 21004—21022

Plasma tau predicts cerebral vulnerability in aging


Serial mediating role of plasma t-tau and cortical FDG uptake on the relationship between cortical thinning and memory deficits in aging. Path analysis showing the serial mediation of higher plasma t-tau and lower FDG uptake in the orbitofronal cortex on the relationship between cortical thinning in the temporal lobe and memory deficits. Numbers along paths are unstandardized regression coefficients with the standard deviation in parenthesis. Asterisks indicate that the direct path as well as the total and indirect effect were statistically significant (*p < 0.05; **p < 0.005; ***p < 0.001). Thicker lines refer to the paths intervening in the three-way indirect effect.