Research Paper Volume 12, Issue 22 pp 23114—23128

Intracellular and extracellular S100A9 trigger epithelial-mesenchymal transition and promote the invasive phenotype of pituitary adenoma through activation of AKT1

Figure 6. The effects of S100A9 in primary PA. (C, D) The downregulation of S100A9 impeded migration and invasion in primary PA (n=5. ***P<0.001, compared with control). (E, F) The cell migration and invasion were also analyzed after treatment with the recombinant S100A9 protein (n=5. ***P<0.001 vs. Control).