Research Paper Volume 12, Issue 22 pp 23217—23232

Alteration of tumor-associated macrophage subtypes mediated by KRT6A in pancreatic ductal adenocarcinoma

Figure 9. The molecular mechanism by which KRT6A regulates TAMs. (A) CEMiTool was used to find gene modules affecting TAMs through KRT6A by dividing TCGA PAAD mRNA-seq data into five groups by the level of KRT6A expression: Grade 0 (G0), Grade 1 (G1), Grade 2 (G2), Grade 3 (G3), and Grade 4 (G4), 6A expression where G0 expressed the lowest amounts of KRT6A (average RPKM = 0) and G4 expressed the highest amounts of KRT6A (average RPKM = 193.24). (B) Expression of a gene module (Module 1) in each PDAC patient. (C) Major genes and the number of genes in each module. (D) Transcription factor PPI network and pathway enrichment of genes in Module 1. (E) Cell type enrichment of genes in Module 1.