**Figure 1.** **A Veen diagram showing intersection of mRNAs expression profiles in GSE8479, GSE1428, and GSE52699 datasets.** (**A**) Multi-volcano plot of DEMs in GSE8479, GSE1428, and GSE52699 datasets. (**B, C**) Association between the expression of DEMs (SEPP1, SV2A, GOT1 and GFOD1) in the indicated datasets. * P < 0.05. (**D**) DE-miRNAs selection using LASSO regression model. The selection of the optimal parameters (lambda) in the LASSO model uses the minimum criterion of 5-fold cross-validation. The dashed line was drawn at the best value using the minimum criterion and 1se (standard error) of the minimum criterion. (**E**) LASSO coefficient profiles of the 4 features. Generation of coefficient outline based on the log (lambda) sequence, where the optimal lambda acquires the characteristics of the 4 non-zero coefficients.