Research Paper Volume 12, Issue 22 pp 23251—23274

Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma

Figure 2. Overall characteristics of circular (circ)RNA expression profiling of distal cholangiocarcinoma (dCCA). (A) The distributions of circRNA expression values after quantile normalization and log2 processing. (T: dCCA tissues; N: paired adjacent normal tissues). (B) The scatter plot describing the difference of circRNA levels between dCCA and normal tissues. The red and blue dots indicate more than 1.5-fold change (FC) in dCCA and normal tissues, respectively. (C) The volcano plot of differentially expressed circRNAs (|log2FC| > 1 and p < 0.05). The red and blue dots represent up- and downregulated circRNAs in tumor. (D) The classifications of circRNAs (up: upregulated circRNAs; down: downregulated circRNAs). (E) The circle diagram describes the location of circRNAs on chromosomes. The red and blue lines represent the up- and downregulated circRNAs in tumor tissues. The segment length indicates the FC value.