Research Paper Volume 12, Issue 22 pp 23251—23274

Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma

Figure 9. Inhibition of hsa_circ_0000673 suppresses cholangiocarcinoma (CCA) cell proliferation, migration, and invasion. (A) Relative expression of hsa_circ_0000673 in four CCA cell lines. (B) Specific small interfering RNA (siRNA) inhibits the expression of hsa_circ_000067 in CCA cells. Cell counting kit-8 assays (C), transwell migration and invasion assays (D), scratch-wound assays (E), and colony formation assays (F) of CCA cells transfected with negative control and si-hsa_circ_0000673. *p < 0.05, **p < 0.01, ***p < 0.001.