Research Paper Volume 12, Issue 20 pp 20862—20879

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice

Figure 1. The expression of inflammatory cytokines in the hippocampus in 5xFAD mice. (A) Representative image of Aβ load stained with Thioflavine S (green) in hippocampus (DG). Scale bar, 100μm. (B) The expression of GFAP, APOE, TNF-α, IL-1β were evaluated by qPCR (n=4). (C) The quantification of serum NfL (n=5). All of the results are shown as mean ± SEM. * P<0.05, ** P<0.01, *** P<0.001, vs WT group.