Research Paper Volume 12, Issue 20 pp 20862—20879

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice


Figure 7. TREM2 overexpression decreases the number of M1 microglia via PI3K-FoxO3a pathway, but increased the number of M2 microglia. (A, B) Meaningful western blot bands (A) and their quantification (B) of CD32 and CD206 (n=4). (CF) M2 and M1 microglia were evaluated with stained CD206 (C) or CD32 (D), respectively, by confocal microscope and their quantitative analysis of CD 206 (E) and CD32 (F). n=4 per group, 9 fields/sample. Scale bar=50 μm. * P<0.05, ** P<0.01, *** P<0.001, vs Sham; # P<0.05, ## P<0.01, ### P<0.001, vs LPS-NC; & P<0.05, && P<0.01, &&& P<0.001, vs LPS-OE. Results were showed as mean ± SEM.