Research Paper Volume 12, Issue 20 pp 20862—20879

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice

Figure 8. A schematic diagram of TREM2 modulating the inflammatory response via PI3K/AKT/FoxO3a pathway in microglia. On the left (red), the result is led from the knockdown of TREM2, while on the right (green) the result is caused by the overexpression of TREM2 receptor.