Research Paper Volume 12, Issue 20 pp 20001—20023

Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

Figure 1. Ccl2 significantly reduced the lifespan of mice with accelerated aging.Ccl2 overexpression was critical for (A) the differential progression in body weight with age, (B) development of features of accelerated aging, as shown in the representative photographs of mice at 20 weeks of age, and (C) reduced lifespan, as shown by Kaplan-Meier survival plots from the wild-type (n=20), LMNAG609G/+ (n=28) and LMNAG609G/+;CGCCL2+/- (n=34) mice. LMNAG609G/+;CGCCL2+/- and LMNAG609G/+ denote progeroid mice overexpressing and not overexpressing Ccl2, respectively.