Research Paper Advance Articles pp 24255—24269

Exploring the mechanism of resistance to sorafenib in two hepatocellular carcinoma cell lines

Figure 4. Significant upstream regulators of functional modules associated with sorafenib resistance in HCC cells. (A) Significant miRNA regulators. The border color of nodes reflects the log (fold change) in HepG2 cells; the inside color reflects the log (fold change) in Huh7 cells. (B) Significant transcription factor (TF) regulators. Nodes are colored as in panel A.