Editorial Volume 12, Issue 20 pp 19828—19829

Liver cholesterol matters

Figure 1. Summary scheme of the cholesterol-mediated hepatocyte and stellate cell crosstalk pathway in NASH.(A) In NASH, elevated cholesterol upregulates TAZ in hepatocytes, and TAZ activates hepatic stellate cells by inducing Ihh. (B) In hepatocyte, ASTER-B/C-mediated plasma membrane cholesterol internalization activates PKA and calcium signaling through soluble adenylyl cyclase (sAC). The resulting increase in RhoA activity inhibits LATS1/2 and promotes TAZ nucleus translocation. As a transcription factor, high level of TAZ enhances Ihh mRNA expression.