Research Paper Volume 13, Issue 1 pp 460—476

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

DHM can extend the Drosophila lifespan. (A) The structure of DHM. (B) DHM treatment extends the lifespan of wDah females. Compared to flies on control food (0μM DHM), flies on 40μM of DHM food have increased median lifespans (p=0.00004, log-rank test - see Supplementary Table 1). (C) The median lifespans of the different concentrations of DHM-treated female flies. The 40μM of DHM extended the median lifespan by 16.07% (from 60.16 to 69.83 days, p=0.02, t-test). The average of 3 independent lifespan assays. The bars are the SE of three repeat experiments. (D) The food intake of the fruit fly on food without and with DHM (ns means “No significant difference”). (E) Lifespan curves of female flies with later-life and life-long treatment on DHM (p=0.0034 and p=1.32× 10-6, log-rank test - see Supplementary Table 1). (F) The fecundity of female flies on DHM treatment (p= 0.571, p=0.0779 and p=0.347; n=100; t-test).

Figure 1. DHM can extend the Drosophila lifespan. (A) The structure of DHM. (B) DHM treatment extends the lifespan of wDah females. Compared to flies on control food (0μM DHM), flies on 40μM of DHM food have increased median lifespans (p=0.00004, log-rank test - see Supplementary Table 1). (C) The median lifespans of the different concentrations of DHM-treated female flies. The 40μM of DHM extended the median lifespan by 16.07% (from 60.16 to 69.83 days, p=0.02, t-test). The average of 3 independent lifespan assays. The bars are the SE of three repeat experiments. (D) The food intake of the fruit fly on food without and with DHM (ns means “No significant difference”). (E) Lifespan curves of female flies with later-life and life-long treatment on DHM (p=0.0034 and p=1.32× 10-6, log-rank test - see Supplementary Table 1). (F) The fecundity of female flies on DHM treatment (p= 0.571, p=0.0779 and p=0.347; n=100; t-test).