Research Paper Volume 13, Issue 1 pp 460—476

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

DHM induces autophagy in Drosophila. (A) The LysoTracker staining in the midguts of control and DHM-treated flies. The number of the lysosomes in the midguts of control and DHM-treated flies counted in per microscope field of view. (p=0.000023, n=6, t-test). Average number of LysoTracker-stained puncta in fly midguts isolated from control or DHM pretreated flies is presented (±SEM) (B) The relative expression levels of atg1, agt8a and atg8b in control and DHM-treated flies (p=0.5024, p=0.0013, p

Figure 5. DHM induces autophagy in Drosophila. (A) The LysoTracker staining in the midguts of control and DHM-treated flies. The number of the lysosomes in the midguts of control and DHM-treated flies counted in per microscope field of view. (p=0.000023, n=6, t-test). Average number of LysoTracker-stained puncta in fly midguts isolated from control or DHM pretreated flies is presented (±SEM) (B) The relative expression levels of atg1, agt8a and atg8b in control and DHM-treated flies (p=0.5024, p=0.0013, p<0.000001 t-test, n=3).