Research Paper Volume 13, Issue 2 pp 2049—2072

Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma

Schematic diagram depicting the potential function of FGL2 in ESCA. M2-like TAMs recruit infiltrating immune cells by upregulating FGL2, producing a microenvironment that promotes the occurrence and development of ESCA. FGL2 levels correlate with infiltrating immune cell levels, and FGL2 promotes immune escape in the esophageal cancer microenvironment. This study has provided new targets for the development of tumor immunotherapies that treat ESCA by reversing the polarization of TAMs into M1-like TAMs.

Figure 10. Schematic diagram depicting the potential function of FGL2 in ESCA. M2-like TAMs recruit infiltrating immune cells by upregulating FGL2, producing a microenvironment that promotes the occurrence and development of ESCA. FGL2 levels correlate with infiltrating immune cell levels, and FGL2 promotes immune escape in the esophageal cancer microenvironment. This study has provided new targets for the development of tumor immunotherapies that treat ESCA by reversing the polarization of TAMs into M1-like TAMs.