Online ISSN: 1945-4589

Volume 13, Issue 2

31 January, 2021
pp 1566—3164

About the Cover

The cover features Figure 3 "Sulforaphane delays age-associated physiological decline“ from Qi et al.


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Table of Contents

Editorials

Dysregulated anti-viral innate immune cascade during aging

Colby Stotesbury, Luis J. Sigal,
https://doi.org/10.18632/aging.202588 pp 1566—1567
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Aging alters immune responses to vaccines

Jennifer Connors, Elias K. Haddad, Constantinos Petrovas,
https://doi.org/10.18632/aging.202598 pp 1568—1570
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Research Papers

COVID-19
Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?

Anna Kovalchuk, Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Slava Ilnytskyy, Igor Kovalchuk, Olga Kovalchuk,
https://doi.org/10.18632/aging.202500 pp 1571—1590
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COVID-19
Coagulation dysfunction in ICU patients with coronavirus disease 2019 in Wuhan, China: a retrospective observational study of 75 fatal cases

Jiaran Shi, Wang Zhang, Ling Sang, Zhaohui Qu, Ming Zhong, Li jiang, Bin Song, Liang Kang, Yun Zhang, Xingxiang Wang, Dingyu Zhang, Xia Zheng,
https://doi.org/10.18632/aging.202223 pp 1591—1607
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COVID-19
Predicting severe or critical symptoms in hospitalized patients with COVID-19 from Yichang, China

Xin Chen, Feng Peng, Xiaoni Zhou, Jiang Zhu, Xin Chen, Yingying Gong, Wang Shupeng, Wenquan Niu,
https://doi.org/10.18632/aging.202261 pp 1608—1619
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COVID-19
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection

Long Chen, Yue Liu, Jiamin Wu, Chao Deng, Jianjun Tan, Huawen Liu, Li Zhong,
https://doi.org/10.18632/aging.202375 pp 1620—1632
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The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice

Fang Zhang, Mert Icyuz, Andrzej Bartke, Liou Y. Sun,
https://doi.org/10.18632/aging.202451 pp 1633—1648
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Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling

Zhimin Qi, Huihui Ji, Monika Le, Hanmei Li, Angela Wieland, Sonja Bauer, Li Liu, Michael Wink, Ingrid Herr,
https://doi.org/10.18632/aging.202512 pp 1649—1670
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Dietary administration of cumin-derived cuminaldehyde induce neuroprotective and learning and memory enhancement effects to aging mice

Zineb Omari, Sasaki Kazunori, Mouad Sabti, Meriem Bejaoui, Abdellatif Hafidi, Chemseddoha Gadhi, Hiroko Isoda,
https://doi.org/10.18632/aging.202516 pp 1671—1685
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Shorter telomeres in children with severe asthma, an indicative of accelerated aging

Florencia M. Barbé-Tuana, Lucas K. Grun, Vinícius Pierdoná, Mariana M. Parisi, Frederico Friedrich, Fátima T.C.R. Guma, Leonardo A. Pinto, Renato T. Stein, Paulo M.C. Pitrez, Marcus H. Jones,
https://doi.org/10.18632/aging.202527 pp 1686—1691
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A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c

Hirofumi Zempo, Su-Jeong Kim, Noriyuki Fuku, Yuichiro Nishida, Yasuki Higaki, Junxiang Wan, Kelvin Yen, Brendan Miller, Roberto Vicinanza, Eri Miyamoto-Mikami, Hiroshi Kumagai, Hisashi Naito, Jialin Xiao, Hemal H. Mehta, Changhan Lee, Megumi Hara, Yesha M. Patel, Veronica W. Setiawan, Timothy M. Moore, Andrea L. Hevener, Yoichi Sutoh, Atsushi Shimizu, Kaname Kojima, Kengo Kinoshita, Yasumichi Arai, Nobuyoshi Hirose, Seiji Maeda, Keitaro Tanaka, Pinchas Cohen,
https://doi.org/10.18632/aging.202529 pp 1692—1717
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Effects of alpha-cyclodextrin on water transport, cell hydration and longevity

Lajos Szente, István Puskás, Tibor Vellai, Horst Lohmann,
https://doi.org/10.18632/aging.202533 pp 1718—1728
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Anserine, HClO-scavenger, protected against cognitive decline in individuals with mild cognitive impairment

Nobutaka Masuoka, Chenxu Lei, Haowei Li, Noriko Inamura, Shigenobu Shiotani, Nobuya Yanai, Kenichiro Sato, Keisuke Sakurai, Tatsuhiro Hisatsune,
https://doi.org/10.18632/aging.202535 pp 1729—1741
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DNA methylation perturbations may link altered development and aging in the lung

Priyadarshini Kachroo, Jarrett D. Morrow, Carrie A. Vyhlidal, Roger Gaedigk, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, Dawn L. DeMeo,
https://doi.org/10.18632/aging.202544 pp 1742—1764
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Screening of Alzheimer’s disease by facial complexion using artificial intelligence

Yumi Umeda-Kameyama, Masashi Kameyama, Tomoki Tanaka, Bo-Kyung Son, Taro Kojima, Makoto Fukasawa, Tomomichi Iizuka, Sumito Ogawa, Katsuya Iijima, Masahiro Akishita,
https://doi.org/10.18632/aging.202545 pp 1765—1772
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Commonalities in biomarkers and phenotypes between mild cognitive impairment and cerebral palsy: a pilot exploratory study

Ted Kheng Siang Ng, Alex Tagawa, Roger Chun-Man Ho, Anis Larbi, Ee Heok Kua, Rathi Mahendran, James J. Carollo, Patricia C. Heyn,
https://doi.org/10.18632/aging.202563 pp 1773—1816
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Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster

Liubov Koval, Nadezhda Zemskaya, Alexander Aliper, Alex Zhavoronkov, Alexey Moskalev,
https://doi.org/10.18632/aging.202572 pp 1817—1841
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Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma

Zhengshuai Song, Zhongyuan Li, Weiwei Han, Chenxi Zhu, Ning Lou, Xuechao Li, Gang Luo, Song Peng, Guohao Li, Ye Zhao, Yonglian Guo,
https://doi.org/10.18632/aging.103638 pp 1842—1858
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Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database

Kun Jin, Shi Qiu, Di Jin, Xianghong Zhou, Xiaonan Zheng, Jiakun Li, Xinyang Liao, Lu Yang, Qiang Wei,
https://doi.org/10.18632/aging.103787 pp 1859—1871
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Multiwalled carbon nanotubes co-delivering sorafenib and epidermal growth factor receptor siRNA enhanced tumor-suppressing effect on liver cancer

Zhili Wen, Yuliang Feng, Youwen Hu, Lingyan Lian, Hongyan Huang, Li Guo, Shanwen Chen, Qian Yang, Moran Zhang, Lijun Wan, Kedong Xu, Degejirifu Degejirifu, Xiaohua Yan,
https://doi.org/10.18632/aging.103905 pp 1872—1882
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CD36 upregulates DEK transcription and promotes cell migration and invasion via GSK-3β/β-catenin-mediated epithelial-to-mesenchymal transition in gastric cancer

Jin Wang, Ti Wen, Zhi Li, Xiaofang Che, Libao Gong, Zihan Jiao, Xiujuan Qu, Yunpeng Liu,
https://doi.org/10.18632/aging.103985 pp 1883—1897
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Effective natural inhibitors targeting poly ADP-ribose polymerase by computational study

Sheng Zhong, Bo Wu, Wenzhuo Yang, Junliang Ge, Xiangheng Zhang, Zhenghe Chen, Hao Duan, Zhenqiang He, Yibing Liu, Hongyu Wang, Yuting Jiang, Zhiyun Zhang, Xinhui Wang, Weihang Li, Naimeng Liu, Xiaoyu Guo, Yonggao Mu,
https://doi.org/10.18632/aging.103986 pp 1898—1912
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Dietary inflammatory potential and risk of sarcopenia: data from national health and nutrition examination surveys

Jiwen Geng, Linghui Deng, Shi Qiu, Haiyang Bian, Boyu Cai, Kun Jin, Xiaonan Zheng, Jiakun Li, Xinyang Liao, Yupei Li, Jiameng Li, Zheng Qin, Zhiwei Cao, Yige Bao, Baihai Su,
https://doi.org/10.18632/aging.202141 pp 1913—1928
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A TP53-based immune prognostic model for muscle-invasive bladder cancer

Hongyan Li, Huayi Lu, Wanli Cui, Yufan Huang, Xuefei Jin,
https://doi.org/10.18632/aging.202150 pp 1929—1946
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Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition

Xiaofeng Yuan, Lianhua Piao, Luhui Wang, Xu Han, Lei Tong, Shijie Shao, Xiaoshuang Xu, Ming Zhuang, Zhiwei Liu,
https://doi.org/10.18632/aging.202158 pp 1947—1961
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Impact of metabolic syndrome on sex hormones and reproductive function: a meta-analysis of 2923 cases and 14062 controls

Lihong Zhou, Liou Han, Mingyao Liu, Jixuan Lu, Shangha Pan,
https://doi.org/10.18632/aging.202160 pp 1962—1971
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Plasma cytokines for predicting diabetic retinopathy among type 2 diabetic patients via machine learning algorithms

Bin Cao, Ning Zhang, Yuanyuan Zhang, Ying Fu, Dong Zhao,
https://doi.org/10.18632/aging.202168 pp 1972—1988
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Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades

Xiuchao Geng, Yuhao Zhang, Qiang Li, Wang Xi, Wentao Yu, Liang Shi, Xiaomeng Lin, Shaoguang Sun, Hong Wang,
https://doi.org/10.18632/aging.202192 pp 1989—2014
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Mendelian randomization study of telomere length and bone mineral density

Fashuai Wu, Yu Huang, Jialu Hu, Zengwu Shao,
https://doi.org/10.18632/aging.202197 pp 2015—2030
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Prognostic value of circulating tumor DNA in pancreatic cancer: a systematic review and meta-analysis

Zengli Fang, Qingcai Meng, Bo Zhang, Si Shi, Jiang Liu, Chen Liang, Jie Hua, Xianjun Yu, Jin Xu, Wei Wang,
https://doi.org/10.18632/aging.202199 pp 2031—2048
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Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma

Xin Yuan, Ya Li, An Zhi Zhang, Chen Hao Jiang, Fan Ping Li, Yu Fang Xie, Jiang Fen Li, Wei Hua Liang, Hai Jun Zhang, Chun Xia Liu, Li Juan Pang, Xi Hua Shen, Feng Li, Jian Ming Hu,
https://doi.org/10.18632/aging.202201 pp 2049—2072
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Decreased expression of JAK1 associated with immune infiltration and poor prognosis in lung adenocarcinoma

Jinlian Cai, Hong Deng, Linlin Luo, Luxia You, Huitian Liao, Yan Zheng,
https://doi.org/10.18632/aging.202205 pp 2073—2088
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Relationship between telomere shortening and age in Korean individuals with mild cognitive impairment and Alzheimer’s disease compared to that in healthy controls

Eun-Hye Lee, Myung-Hoon Han, Jungsoon Ha, Hyun-Hee Park, Seong-Ho Koh, Seong Hye Choi, Jae-Hong Lee,
https://doi.org/10.18632/aging.202206 pp 2089—2100
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miR-588 is a prognostic marker in gastric cancer

Yongyi Chen, Jie Zhang, Wangang Gong, Wumin Dai, Xiaohong Xu, Songxiao Xu,
https://doi.org/10.18632/aging.202212 pp 2101—2117
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IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice

Tahir Muhammad, Yanling Wan, Qianqian Sha, Jianfeng Wang, Tao Huang, Yongzhi Cao, Mengjing Li, Xiaochen Yu, Yingying Yin, Wai Yee Chan, Zi-Jiang Chen, Li You, Gang Lu, Hongbin Liu,
https://doi.org/10.18632/aging.202214 pp 2118—2134
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Prenatal diagnosis and molecular cytogenetic identification of small supernumerary marker chromosomes: analysis of three prenatal cases using chromosome microarray analysis

Huili Xue, Xuemei Chen, Min Lin, Na Lin, Hailong Huang, Aili Yu, Liangpu Xu,
https://doi.org/10.18632/aging.202220 pp 2135—2148
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Identification of SCARA3 with potential roles in metabolic disorders

Hui Peng, Qi Guo, Tian Su, Ye Xiao, Chang-Jun Li, Yan Huang, Xiang-Hang Luo,
https://doi.org/10.18632/aging.202228 pp 2149—2167
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Comprehensive analysis of immune infiltration and gene expression for predicting survival in patients with sarcomas

Hongmin Chen, Yijiang Song, Chuangzhong Deng, Yanyang Xu, Huaiyuan Xu, Xiaojun Zhu, Guohui Song, Qinglian Tang, Jinchang Lu, Jin Wang,
https://doi.org/10.18632/aging.202229 pp 2168—2183
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Nomograms based on pre-operative parametric for prediction of short-term mortality in acute myocardial infarction patients treated invasively

Qingjie Wang, Wei Qian, Zhiqin Sun, Wenwu Zhu, Yu Liu, Xin Chen, Yuan Ji, Ling Sun,
https://doi.org/10.18632/aging.202230 pp 2184—2197
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Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis

Yanyao Deng, Hongwei Zhu, Le Xiao, Chao Liu, Xiangrui Meng,
https://doi.org/10.18632/aging.202234 pp 2198—2211
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Role of FUT8 expression in clinicopathology and patient survival for various malignant tumor types: A systematic review and meta-analysis

Minxing Ma, Guoxiong Han, Yi Wang, Ziyan Zhao, Feng Guan, Xiang Li,
https://doi.org/10.18632/aging.202239 pp 2212—2230
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Matrix stiffness regulates myocardial differentiation of human umbilical cord mesenchymal stem cells

Yingying Sun, Jingwei Liu, Ziran Xu, Xiaoxuan Lin, Xiaoling Zhang, Lisha Li, Yulin Li,
https://doi.org/10.18632/aging.202244 pp 2231—2250
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β-Arrestin-2 attenuates hepatic ischemia-reperfusion injury by activating PI3K/Akt signaling

Xiaolong Chen, Junbin Zhang, Long Xia, Li Wang, Hui Li, Huilin Liu, Jing Zhou, Zhiying Feng, Hai Jin, JianXu Yang, Yang Yang, Bin Wu, Lei Zhang, Guihua Chen, Genshu Wang,
https://doi.org/10.18632/aging.202246 pp 2251—2263
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Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer

Yizhuo Wang, Liping Zhang, Na Wei, Yue Sun, Weiyun Pan, Yan Chen,
https://doi.org/10.18632/aging.202247 pp 2264—2278
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The clinicopathological significance and prognostic value of programmed death-ligand 1 in prostate cancer: a meta-analysis of 3133 patients

Haixiang Shen, Jin Liu, Guoliang Sun, Libin Yan, Qinchen Li, Zhize Wang, Liping Xie,
https://doi.org/10.18632/aging.202248 pp 2279—2293
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Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis

Mao-Hui Feng, Zhi-Xiao Li, Qian Wang, Anne Manyande, Yu-Juan Li, Shun-Yuan Li, Weiguo Xu, Hong-Bing Xiang,
https://doi.org/10.18632/aging.202250 pp 2294—2309
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B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8+ T cells in pancreatic cancer

Hongkai Zhuang, Zixuan Zhou, Zedan Zhang, Xinming Chen, Zuyi Ma, Shanzhou Huang, Yuanfeng Gong, Chuanzhao Zhang, Baohua Hou,
https://doi.org/10.18632/aging.202255 pp 2310—2329
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CPEB3 regulates neuron-specific alternative splicing and involves neurogenesis gene expression

Wenrui Qu, Hongjuan Jin, Bing-Peng Chen, Jun Liu, Rui Li, Wenlai Guo, Heng Tian,
https://doi.org/10.18632/aging.202259 pp 2330—2347
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Upregulation of HOTAIRM1 increases migration and invasion by glioblastoma cells

Peng Xie, Xiang Li, Rui Chen, Yue Liu, DaChao Liu, Wenguang Liu, Gang Cui, Jinjing Xu,
https://doi.org/10.18632/aging.202263 pp 2348—2364
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The mutational pattern of homologous recombination-related (HRR) genes in Chinese colon cancer and its relevance to immunotherapy responses

Pei Zhou, Xueying Wu, Huan Chen, Ying Hu, Henghui Zhang, Lijia Wu, Ying Yang, Beibei Mao, Huaqing Wang,
https://doi.org/10.18632/aging.202267 pp 2365—2378
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Dysregulation of FOXD2-AS1 promotes cell proliferation and migration and predicts poor prognosis in oral squamous cell carcinoma: a study based on TCGA data

Zheqi Liu, Wenkai Zhou, Chengzhong Lin, Xiaoning Wang, Xu Zhang, Yu Zhang, Rong Yang, Wantao Chen, Wei Cao,
https://doi.org/10.18632/aging.202268 pp 2379—2396
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Immune profile of the tumor microenvironment and the identification of a four-gene signature for lung adenocarcinoma

Tao Fan, Mingchuang Zhu, Liyu Wang, Yu Liu, He Tian, Yujia Zheng, Fengwei Tan, Nan Sun, Chunxiang Li, Jie He,
https://doi.org/10.18632/aging.202269 pp 2397—2417
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Immune-related gene signature predicts overall survival of gastric cancer patients with varying microsatellite instability status

Ruyue Tian, Jiexuan Hu, Xiao Ma, Lei Liang, Shuilong Guo,
https://doi.org/10.18632/aging.202271 pp 2418—2435
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FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway

Xin Xu, Yidi Chen, Danyang Zhu, Tong Zhao, Rui Xu, Jiaying Wang, Lihong Hu, Xu Shen,
https://doi.org/10.18632/aging.202275 pp 2436—2458
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Identification of long non-coding RNA signatures for squamous cell carcinomas and adenocarcinomas

Suyan Tian, Mingbo Tang, Jialin Li, Chi Wang, Wei Liu,
https://doi.org/10.18632/aging.202278 pp 2459—2479
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Integrated bioinformatic analysis of RNA binding proteins in hepatocellular carcinoma

Ling Wang, Zhen Zhang, Yuan Li, Yanyan Wan, Baocai Xing,
https://doi.org/10.18632/aging.202281 pp 2480—2505
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Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis

Min Liu, Weixin Li, Fuxing Song, Ling Zhang, Xianjun Sun,
https://doi.org/10.18632/aging.202284 pp 2506—2518
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Identification of key modules and genes associated with breast cancer prognosis using WGCNA and ceRNA network analysis

Xin Yin, Pei Wang, Tianshu Yang, Gen Li, Xu Teng, Wei Huang, Hefen Yu,
https://doi.org/10.18632/aging.202285 pp 2519—2538
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Silencing of LOC389641 impairs cell proliferation and induces autophagy via EGFR/MET signaling in lung adenocarcinoma

Lei Xiao, Yu Li, Xiaofei Zeng, Zhiqing Zhou, Shengmin Hu, Shenglin Zhang, Yi Zhou, Zhan Zhang, Han Zhao, Huijie Zhao, David G. Beer, Rui Mao, Guoan Chen,
https://doi.org/10.18632/aging.202286 pp 2539—2552
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TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling

Ke Lin, Wu Luo, Jueqian Yan, Siyuan Shen, Qirui Shen, Jun Wang, Xinfu Guan, Gaojun Wu, Weijian Huang, Guang Liang,
https://doi.org/10.18632/aging.202290 pp 2553—2574
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β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial–mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway

Kun Zou, Zongjuan Li, Yang Zhang, Lin Mu, Miao Chen, Ruonan Wang, Wuguo Deng, Lijuan Zou, Jiwei Liu,
https://doi.org/10.18632/aging.202291 pp 2575—2592
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Antitumor effect of poly lactic acid nanoparticles loaded with cisplatin and chloroquine on the oral squamous cell carcinoma

Qiang Li, Xia Liu, Wei Yan, Yong Chen,
https://doi.org/10.18632/aging.202297 pp 2593—2603
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Knockdown of CENPF inhibits the progression of lung adenocarcinoma mediated by ERβ2/5 pathway

Tang Hexiao, Bai Yuquan, Xiong Lecai, Wei Yanhong, Shen Li, Hu Weidong, Xu Ming, Zhou Xuefeng, Pan Gaofeng, Zhang Li, Zhu Minglin, Tang Zheng, Yang Zetian, Zhou Xiao, Cai Yi, Michael Lanuti, Zhao Jinping,
https://doi.org/10.18632/aging.202303 pp 2604—2625
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LncRNA CYTOR affects the proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells by regulating the miR-125b-5p/KIAA1522 axis

Bo Hu, Xiao-Bo Yang, Xu Yang, Xin-Ting Sang,
https://doi.org/10.18632/aging.202306 pp 2626—2639
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MiR-16-5p suppresses myofibroblast activation in systemic sclerosis by inhibiting NOTCH signaling

Qicen Yao, Yixi Xing, Zaiyan Wang, Jin Liang, Qianqi Lin, Meiqiong Huang, Yiling Chen, Bo Lin, Xiayu Xu, Weifei Chen,
https://doi.org/10.18632/aging.202308 pp 2640—2654
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Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MyD88 signaling axis

Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, Lianxiang Luo,
https://doi.org/10.18632/aging.202309 pp 2655—2667
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Notch-1 promotes the malignant progression of osteosarcoma through the activation of cell division cycle 20

Yuan Gao, Lunhao Bai, Guanning Shang,
https://doi.org/10.18632/aging.202314 pp 2668—2680
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Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury

Kexing Wan, Fuxiu Mao, Qiongqiong Li, Limin Wang, Zhiguo Wei, Ping Wang, Xinhua Liao, Mengsi Xu, Jin Huang, Zemin Pan, Chengtan Wang, Jian Luo, Rui Gao, Shangquan Gan,
https://doi.org/10.18632/aging.202318 pp 2681—2699
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Identification of the ceRNA networks in α-MSH-induced melanogenesis of melanocytes

Ling Jiang, Jinhua Huang, Yibo Hu, Li Lei, Yujie Ouyang, Yan Long, Hui Li, Si Li, Lun Yang, Yan Yang, Lihua Huang, Hong Xiang, Rong Xiao, Jing Chen, Qinghai Zeng,
https://doi.org/10.18632/aging.202320 pp 2700—2726
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Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation

Long Jin, Hai-Ying Zhu, Xiang-Jin Kang, Li-Ping Lin, Pu-Yao Zhang, Tao Tan, Yang Yu, Yong Fan,
https://doi.org/10.18632/aging.202323 pp 2727—2749
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ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

Pan Long, Mengshan He, Weiming Yan, Wei Chen, Dongyu Wei, Siwang Wang, Zuoming Zhang, Wei Ge, Tao Chen,
https://doi.org/10.18632/aging.202325 pp 2750—2767
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PTPN2 negatively regulates macrophage inflammation in atherosclerosis

Xiaorong Hu, Ruisong Ma, Jianlei Cao, Xianjin Du, Xinyong Cai, Yongzhen Fan,
https://doi.org/10.18632/aging.202326 pp 2768—2779
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Identification of a novel immune microenvironment signature predicting survival and therapeutic options for bladder cancer

Yilin Yan, Zhengnan Huang, Jinming Cai, Pengfei Tang, Fang Zhang, Mingyue Tan, Bing Shen,
https://doi.org/10.18632/aging.202327 pp 2780—2802
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SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma

Baozhu Zhang, Qing Zhou, Qiankun Xie, Xiaohui Lin, Wenqiang Miao, Zhaoguang Wei, Tingting Zheng, Zuoliang Pang, Haosheng Liu, Xi Chen,
https://doi.org/10.18632/aging.202329 pp 2803—2821
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Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice

Dongdong Huang, Felix Siaw-Debrah, Hua Wang, Sheng Ye, Kankai Wang, Ke Wu, Ying Zhang, Hao Wang, Chaojie Yao, Jiayu Chen, Lin Yan, Chun-Li Zhang, Qichuan Zhuge, Jianjing Yang,
https://doi.org/10.18632/aging.202334 pp 2822—2850
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A novel methylation signature predicts inferior outcome of patients with PDAC

Minqi Gu, Jing Sun, Shunhao Zhang, Jing Chen, Guihua Wang, Shaoqing Ju, Xudong Wang,
https://doi.org/10.18632/aging.202347 pp 2851—2863
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The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis

Xuhui Yang, Lifei Meng, Yuang Zhong, Fengqing Hu, Lei Wang, Mingsong Wang,
https://doi.org/10.18632/aging.202352 pp 2864—2884
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Serum response factor, a novel early diagnostic biomarker of acute kidney injury

Long Zhao, Chenyu Li, Chen Guan, Ning Song, Hong Luan, Congjuan Luo, Wei Jiang, Quandong Bu, Yanfei Wang, Lin Che, Yan Xu,
https://doi.org/10.18632/aging.202381 pp 2885—2894
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Identification of RNA-binding protein SNRPA1 for prognosis in prostate cancer

Penghui Yuan, Le Ling, Xintao Gao, Taotao Sun, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang, Bo Liu,
https://doi.org/10.18632/aging.202387 pp 2895—2911
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Systems pharmacology dissection of Epimedium targeting tumor microenvironment to enhance cytotoxic T lymphocyte responses in lung cancer

Chao Huang, Zhihua Li, Jinglin Zhu, Xuetong Chen, Yuanyuan Hao, Ruijie Yang, Ruifei Huang, Jun Zhou, Zhenzhong Wang, Wei Xiao, Chunli Zheng, Yonghua Wang,
https://doi.org/10.18632/aging.202410 pp 2912—2940
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Up-regulation of miR-204 inhibits proliferation, invasion and apoptosis of gallbladder cancer cells by targeting Notch2

Baohua Zhang, Haiyan Cui, Yinping Sun, Xinmei Wang, Qing Jia, Jing Li, Yingchun Yin, Xiaoyu Sun, Huirong Xu, Hongwei Li, Famei Xu, Jiansheng Rong,
https://doi.org/10.18632/aging.202444 pp 2941—2958
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A novel five-lncRNA signature panel improves high-risk survival prediction in patients with cholangiocarcinoma

Xiaozai Xie, Yi Wang, Sina Zhang, Jialiang Li, Zhengping Yu, Xiwei Ding, Longyun Ye, Peirong Gong, Qiandong Zhu, Junjian Li, Ziyan Chen, Xinfei Yao, Zhiyong Du, Qiqiang Zeng, Hanbin Chen, Zhen Yang, Gang Chen,
https://doi.org/10.18632/aging.202446 pp 2959—2981
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Excessive fibroblast growth factor 23 promotes renal fibrosis in mice with type 2 cardiorenal syndrome

Huixin Hao, Siyuan Ma, Cankun Zheng, Qiancheng Wang, Hairuo Lin, Zhenhuan Chen, Jiahe Xie, Lin Chen, Kaitong Chen, Yuegang Wang, Xiaobo Huang, Shiping Cao, Wangjun Liao, Jianping Bin, Yulin Liao,
https://doi.org/10.18632/aging.202448 pp 2982—3009
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Efficacy of melatonin in animal models of intracerebral hemorrhage: a systematic review and meta-analysis

Liuwang Zeng, Yuwei Zhu, Xiangyu Hu, Haiyun Qin, Jiayu Tang, Zhiping Hu, Chunli Chen,
https://doi.org/10.18632/aging.202457 pp 3010—3030
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Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

Qiang Chen, Yu-Qing Lei, Jian-Feng Liu, Zeng-Chun Wang, Hua Cao,
https://doi.org/10.18632/aging.202460 pp 3031—3044
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Transplantation of bone marrow-derived mesenchymal stem cells with silencing of microRNA-138 relieves pelvic organ prolapse through the FBLN5/IL-1β/elastin pathway

Bing Zhao, Qing Sun, Yazhou Fan, Xinming Hu, Linyu Li, Junmin Wang, Shihong Cui,
https://doi.org/10.18632/aging.202465 pp 3045—3059
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Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

Zhongfei Zhang, Xiaoxiong Zou, Run Zhang, Yu Xie, Zhiming Feng, Feng Li, Jianbang Han, Haitao Sun, Qian Ouyang, Shiting Hua, Bingke Lv, Tian Hua, Zhizheng Liu, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang,
https://doi.org/10.18632/aging.202466 pp 3060—3079
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Constructing a ceRNA-immunoregulatory network associated with the development and prognosis of human atherosclerosis through weighted gene co-expression network analysis

Yaozhong Liu, Na Liu, Qiming Liu,
https://doi.org/10.18632/aging.202486 pp 3080—3100
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Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway

Ye-Ping Xu, Yun-Na Tao, You-Ping Wu, Jing Zhang, Wei Jiao, Yu-Hai Wang, Tao Chen,
https://doi.org/10.18632/aging.202503 pp 3101—3111
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Identification of core genes for early diagnosis and the EMT modulation of ovarian serous cancer by bioinformatics perspective

Yanna Zhang, Xun Wang, Xiancheng Chen,
https://doi.org/10.18632/aging.202524 pp 3112—3145
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Review

Medulloblastoma in adults – reviewing the literature from a surgeon’s point of view

Thomas Eibl, Alexander Hammer, Eduard Yakubov, Cristiane Blechschmidt, Alexander Kalisch, Hans-Herbert Steiner,
https://doi.org/10.18632/aging.202568 pp 3146—3160
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Corrections

Correction for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury

Yan Sun, Shiting Dai, Jin Tao, Yunlong Li, Ziqi He, Quan Liu, Jiawen Zhao, Yaoliang Deng, Juening Kang, Xuepei Zhang, Sixing Yang, Yunlong Liu,
https://doi.org/10.18632/aging.202587 pp 3161
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Correction for: Circ‐BPTF promotes bladder cancer progression and recurrence through the miR‐31‐5p/RAB27A axis

Junming Bi, Hongwei Liu, Zijian Cai, Wei Dong, Ning Jiang, Meihua Yang, Jian Huang, Tianxin Lin,
https://doi.org/10.18632/aging.202597 pp 3162—3164
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