Research Paper Volume 13, Issue 2 pp 2049—2072

Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma

Identification of cytokines with significantly different levels in ESCC cells co-cultured with macrophages. (A) Schematic of the process of co-culturing macrophages and ESCC cells (EC109 and EC9706). (B, C) The levels of IL-10, MMP9, CCL5, TIM-3, IL-13, VCAM1, M-CSF and FGF-7 in EC109 cells cultured alone, co-cultured with M0 macrophages or co-cultured with M2 macrophages. (D, E) The levels of IL-10, MMP9, CCL5, TIM-3, IL-13, VCAM1, M-CSF and FGF-7 in EC9706 cells cultured alone, co-cultured with M0 macrophages or co-cultured with M2 macrophages. MØ, M0 macrophages; M2, M2-like TAMs.

Figure 7. Identification of cytokines with significantly different levels in ESCC cells co-cultured with macrophages. (A) Schematic of the process of co-culturing macrophages and ESCC cells (EC109 and EC9706). (B, C) The levels of IL-10, MMP9, CCL5, TIM-3, IL-13, VCAM1, M-CSF and FGF-7 in EC109 cells cultured alone, co-cultured with M0 macrophages or co-cultured with M2 macrophages. (D, E) The levels of IL-10, MMP9, CCL5, TIM-3, IL-13, VCAM1, M-CSF and FGF-7 in EC9706 cells cultured alone, co-cultured with M0 macrophages or co-cultured with M2 macrophages. MØ, M0 macrophages; M2, M2-like TAMs.