Theory Article Volume 12, Issue 22 pp 22356—22369

Proposing a minimal set of metrics and methods to predict probabilities of amyloidosis disease and onset age in individuals

Figure 1. Minimal kinetic mechanism for TTR homeostasis. TTR unfolded* is a transient intermediate that may not accumulate to a measurable degree. It is assumed that degradation of fibrils and aggregate is negligible compared to degradation of monomer (kDeg2<<Deg1).