Theory Article Volume 12, Issue 22 pp 22356—22369

Proposing a minimal set of metrics and methods to predict probabilities of amyloidosis disease and onset age in individuals

Figure 3. (A) Canonical WT TTR sequence, peptides frequently observed in mass spectrometry experiments are shown in blue. Highlighted residues have published chemical modifications that could serve as fold-stability markers (B) The TTR monomer folds into two discrete beta sheets and a small alpha helix (PDB structure 1BZE) (C) The consensus model of the tetramer has four monomers (each in a different color) interacting along the edges of the beta sheets which would stabilize the protein structure in these regions (Model incorporates PDB 1BZE and 1BZ8).