Theory Article Volume 12, Issue 22 pp 22356—22369

Proposing a minimal set of metrics and methods to predict probabilities of amyloidosis disease and onset age in individuals

Figure 5. TTR structure causes modified susceptibility to denaturation for different parts of the sequence. Individual measurements (triangles) were fit across the denaturant concentrations to calculate the midpoint (vertical line) and confidence interval of the midpoint (shaded area) for two representative peptides (Panel A: amino acids 43-55, Panel B: amino acids 101-123).