Research Paper Volume 13, Issue 2 pp 2101—2117

miR-588 is a prognostic marker in gastric cancer

Differential expression of miR-588 was significantly associated with GC cell proliferation in vivo and is a prognostic markers for GC patient survival (n = 876). (A) High expression of miR-588 significantly inhibited GC cell proliferation in vivo. (B) High expression of miR-588 significantly downregulated Ki-67 expression in nude mice tumors. (C) Immunohistochemistry analysis of Ki-67 expression in control, vector, and miR-588 overexpression nude mice tumors tissues. (D) Hematoxylin and eosin staining was used for different groups of nude mice tumors. (E–H) High levels of miR-588, CXCL5, CXCL9, and CXCL10 were associated with prolonged survival of GC patients.

Figure 5. Differential expression of miR-588 was significantly associated with GC cell proliferation in vivo and is a prognostic markers for GC patient survival (n = 876). (A) High expression of miR-588 significantly inhibited GC cell proliferation in vivo. (B) High expression of miR-588 significantly downregulated Ki-67 expression in nude mice tumors. (C) Immunohistochemistry analysis of Ki-67 expression in control, vector, and miR-588 overexpression nude mice tumors tissues. (D) Hematoxylin and eosin staining was used for different groups of nude mice tumors. (EH) High levels of miR-588, CXCL5, CXCL9, and CXCL10 were associated with prolonged survival of GC patients.