Research Paper Volume 13, Issue 2 pp 2168—2183

Comprehensive analysis of immune infiltration and gene expression for predicting survival in patients with sarcomas

Comparisons of differentially expressed genes (DEGs) with immune scores and stromal scores. (A, B) The 100 top differentially expressed genes of high- and low- immune scores and stromal scores. The cohort was divided into high- and low-score groups based on the median. (C) The proportion of immune cells estimated by the CIBERSORT algorithm with outputs in which PD–F) Enrichment analysis of differentially expressed genes between groups with high and low immune scores. DDLPS: dedifferentiated liposarcoma, LMS: leiomyosarcoma, MFS: myxofibrosarcoma, MPNST: malignant peripheral nerve sheath tumor, SS: synovial sarcoma and UPS: undifferentiated pleomorphic sarcoma.

Figure 2. Comparisons of differentially expressed genes (DEGs) with immune scores and stromal scores. (A, B) The 100 top differentially expressed genes of high- and low- immune scores and stromal scores. The cohort was divided into high- and low-score groups based on the median. (C) The proportion of immune cells estimated by the CIBERSORT algorithm with outputs in which P<0.05 in 119 sarcoma samples. (DF) Enrichment analysis of differentially expressed genes between groups with high and low immune scores. DDLPS: dedifferentiated liposarcoma, LMS: leiomyosarcoma, MFS: myxofibrosarcoma, MPNST: malignant peripheral nerve sheath tumor, SS: synovial sarcoma and UPS: undifferentiated pleomorphic sarcoma.