Research Paper Volume 13, Issue 2 pp 2198—2211

Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis

Circ

Figure 1. Circ_0005198 expression was upregulated in glioma tissues, serum samples and cells. (A) qRT-PCR was used to measure the expression of circ_0005198 in 10 low-grade (stage l-ll) glioma tissues, 10 high-grade (stage lll-IV) glioma tissues and 15 normal tissues. (B) The expression of circ_0005198 in serum was assessed by qRT-PCR. (C) Circ_0005198 expression was detected by qRT-PCR in normal human astrocytes (NHAs) and glioma cell lines (U87, U251, U138 and LN18). (D) The expression of circ_0005198 in glioma cells (U138 and LN18) and TMZ-resistant glioma cells (U138/TMZ and LN18/TMZ) was assessed by qRT-PCR. *P < 0.05, **P< 0.01.