Research Paper Volume 13, Issue 2 pp 2264—2278

Silencing LINC00482 inhibits tumor-associated inflammation and angiogenesis through down-regulation of MMP-15 via FOXA1 in bladder cancer

LINC00482 is highly expressed in bladder cancer tissues and cells. (A) The comparison of LINC00482 expression between the bladder cancer and adjacent normal tissues detected by RT-qPCR, n = 84, * p vs. adjacent normal tissues; (B) the expression of LINC00482 in 4 human bladder cancer cell lines and human normal bladder epithelial cells (SV-HUC-1) detected by RT-qPCR, * p vs. SV-HUC-1 cells; (C) the localization of LINC00482 in different cells by online analysis; (D) subcellular localization of LINC00482 detected by RNA-FISH (× 400). The measurement data were presented as mean ± standard deviations. Paired t-test was used for intra-group comparison, while comparisons among multiple groups were analyzed by one-way analysis of variance, followed by Tukey’s post-hoc test. Experiments were repeated three times.

Figure 2. LINC00482 is highly expressed in bladder cancer tissues and cells. (A) The comparison of LINC00482 expression between the bladder cancer and adjacent normal tissues detected by RT-qPCR, n = 84, * p < 0.05 vs. adjacent normal tissues; (B) the expression of LINC00482 in 4 human bladder cancer cell lines and human normal bladder epithelial cells (SV-HUC-1) detected by RT-qPCR, * p < 0.05 vs. SV-HUC-1 cells; (C) the localization of LINC00482 in different cells by online analysis; (D) subcellular localization of LINC00482 detected by RNA-FISH (× 400). The measurement data were presented as mean ± standard deviations. Paired t-test was used for intra-group comparison, while comparisons among multiple groups were analyzed by one-way analysis of variance, followed by Tukey’s post-hoc test. Experiments were repeated three times.