Research Paper Volume 13, Issue 2 pp 2330—2347

CPEB3 regulates neuron-specific alternative splicing and involves neurogenesis gene expression

Integrated analysis of CPEB3-bound genes and the regulated alternative splicing events (RASE) in response to CPEB3 overexpression. (A) The overlap of CPEB3-bound peaks with CPEB3-regulated alternative splicing events. (B)Top 10 GO biological process in which the overlapped genes in A were enriched. (C) Top 10 KEGG pathways in which the overlapped genes in A were enriched. (D) The CG motifs over-represented in CPEB3 peaks overlapped with RASEs. The motifs were searched by running HOMER pipeline. (E–G) The reads density landscape of CPEB3-binding peaks on DEGs and RASEs (left). RIP-qPCR validation of the CPEB3 binding a peak was showed (right). The asterisk (*) indicates *P

Figure 5. Integrated analysis of CPEB3-bound genes and the regulated alternative splicing events (RASE) in response to CPEB3 overexpression. (A) The overlap of CPEB3-bound peaks with CPEB3-regulated alternative splicing events. (B)Top 10 GO biological process in which the overlapped genes in A were enriched. (C) Top 10 KEGG pathways in which the overlapped genes in A were enriched. (D) The CG motifs over-represented in CPEB3 peaks overlapped with RASEs. The motifs were searched by running HOMER pipeline. (EG) The reads density landscape of CPEB3-binding peaks on DEGs and RASEs (left). RIP-qPCR validation of the CPEB3 binding a peak was showed (right). The asterisk (*) indicates *P < 0.05,** P < 0.01.