Figure 3. Mutations in HRR genes are associated with tumor immunogenicity and immune activity. Box plots showing the scores of immunogenic mutations, immunogenic indels, cytotoxic cells, exhausted CD8+ T cells, NK cells and IFN-γ signatures in the TCGA (A), TCGA MSI-H (B) AND TCGA MSS (C) cohorts. The scores for immunogenic mutations and indels are shown in log2-transformed format. P values were calculated with the Mann–Whitney U test; the box shows the upper and lower quartiles (* P < 0.05; ** P < 0.01; *** P < 0.001; ns, P > 0.05).