Research Paper Volume 13, Issue 2 pp 2365—2378

The mutational pattern of homologous recombination-related (HRR) genes in Chinese colon cancer and its relevance to immunotherapy responses

HRR-mut status is associated with a favorable therapeutic response to ICIs. Kaplan–Meier survival curves showing the OS times of patients stratified by HRR-mut/wt status in the MSK-IMPACT (A) and TCGA (B) cohorts. Kaplan–Meier survival curves showing the OS times of patients stratified by HRR-mut/wt status in the MSK-IMPACT MSS (TMB-L) (C) and TCGA MSS (D) cohorts. P values were calculated with the log-rank test.

Figure 4. HRR-mut status is associated with a favorable therapeutic response to ICIs. Kaplan–Meier survival curves showing the OS times of patients stratified by HRR-mut/wt status in the MSK-IMPACT (A) and TCGA (B) cohorts. Kaplan–Meier survival curves showing the OS times of patients stratified by HRR-mut/wt status in the MSK-IMPACT MSS (TMB-L) (C) and TCGA MSS (D) cohorts. P values were calculated with the log-rank test.