Research Paper Volume 13, Issue 2 pp 2418—2435

Immune-related gene signature predicts overall survival of gastric cancer patients with varying microsatellite instability status

Prognostic analyses used risk score model. Candidate genes selected by univariate Cox regression were further analyzed in a multivariate Cox model for all MSI-L/MSS and MSI-H samples. The 17 prognostic genes of MSH patients determined by univariate Cox regression and Kaplan-Meier survival analysis were analyzed in a multivariate Cox model and 3 genes were acquired to construct a predictive model. (A, D, G) The distribution of risk score, survival status, and expression heat map. (B, E, H) The Kaplan-Meier curves for low-risk and high-risk groups. (C, F, I) The ROC curves for predicting OS by the risk score. AUC, area under the curve; ROC, receiver operator characteristic; OS, overall survival.

Figure 3. Prognostic analyses used risk score model. Candidate genes selected by univariate Cox regression were further analyzed in a multivariate Cox model for all MSI-L/MSS and MSI-H samples. The 17 prognostic genes of MSH patients determined by univariate Cox regression and Kaplan-Meier survival analysis were analyzed in a multivariate Cox model and 3 genes were acquired to construct a predictive model. (A, D, G) The distribution of risk score, survival status, and expression heat map. (B, E, H) The Kaplan-Meier curves for low-risk and high-risk groups. (C, F, I) The ROC curves for predicting OS by the risk score. AUC, area under the curve; ROC, receiver operator characteristic; OS, overall survival.