**Figure 2.** **Alpha and beta diversity of Normal Aging and MAP groups.** (**A**) Chao 1’s, (**B**) Shannon’s alpha diversity indexes comparing Normal Aging and three time points of MAP groups. p* values of Mann-Whitney U test described significant difference from each other at two-sided p values of 0.05. In each box plot, median line, + mean, upper and lower quartiles, upper and lower extremes and whiskers are presented. (**C**) Weighted (**D**) Unweighted Unifrac principal coordinates analysis (PCoA) for beta diversity comparing Normal Aging and three time points of MAP groups. The groups of the subjects are represented by four different color-coded symbols with sample size in parenthesis in the legend. MAP= Mindful Awareness Program.