Research Paper Advance Articles pp 24371—24393

Mental awareness improved mild cognitive impairment and modulated gut microbiome

Figure 5. Comparison of four blood biomarkers in Normal Aging and MAP groups. (A) Mean of telomere length over time in the MAP intervention study. P values were calculated by Wilcoxon matched-pairs signed-rank t test comparing the two groups. The samples of Normal Aging were not measured for telomere length. (B) Concentrations of BDNF (pg/ml), (C) DHEAS (ng/ml) and (D) hs-CRP (μg/ml) comparing Normal Aging and three timepoints of MAP groups. Significant different two-tailed p values of Mann-Whitney U test are presented as **** p < 0.0001, *** p ≥ 0.0001 - < 0.001, ** p ≥ 0.001 - < 0.01, * p ≥ 0.01- < 0.05. In each box plot, median line, + mean, upper and lower quartiles, upper and lower extremes and whiskers are presented. The groups of the subjects represented by three different color-coded symbols with sample size are indicated in parenthesis in the legend. MAP= Mindful Awareness Program, BDNF= Brain-derived neurotrophic factor, DHEAS= Dehydroepiandrosterone sulfate, hs-CRP= High sensitive C-reactive protein.