Research Paper Volume 13, Issue 3 pp 3518—3535

High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma


Figure 11. RRM2 promoted cell proliferation and invasion and regulated cell cycle progression of lung cancer cells. (A) CCK-8 proliferation curve of A549 cells transfected with si-RRM2, O-RRM2, si-NC, and O-Control; (B) Transwell assays were performed to evaluate the role of RRM2 on cell invasion; (C) The cell cycle analyzed of A549 cells by flow cytometry; (D) RRM2-associated signaling pathways were determined by western blot assay. *indicates a p-value < 0.05, and **indicates a p-value < 0.01.