Research Paper Volume 13, Issue 1 pp 1314—1331

rTMS modulates precuneus-hippocampal subregion circuit in patients with subjective cognitive decline

Differences in HIPsub functional connectivity between SCD subjects and CN before rTMS treatment after controlling for age, sex, education, ITV, and FD (p  405 mm3. (A) HIPe-subregion and different brain regions of the HIPe functional connectivity between CN and SCD subjects. The bar chart shows the quantitative comparison of functional connectivity in these regions. (B) HIPc-subregion and different brain regions of the HIPc functional connectivity between CN and SCD subjects. The bar chart depicts the quantitative comparison of functional connectivity in these regions. (C) HIPp-subregion and different brain regions of the HIPp functional connectivity between CN and SCD subjects. The bar chart indicates the quantitative comparison of functional connectivity in these regions. * PTFCE-FDR

Figure 4. Differences in HIPsub functional connectivity between SCD subjects and CN before rTMS treatment after controlling for age, sex, education, ITV, and FD (p < 0.05, TFCE-FDR correction, cluster size > 405 mm3. (A) HIPe-subregion and different brain regions of the HIPe functional connectivity between CN and SCD subjects. The bar chart shows the quantitative comparison of functional connectivity in these regions. (B) HIPc-subregion and different brain regions of the HIPc functional connectivity between CN and SCD subjects. The bar chart depicts the quantitative comparison of functional connectivity in these regions. (C) HIPp-subregion and different brain regions of the HIPp functional connectivity between CN and SCD subjects. The bar chart indicates the quantitative comparison of functional connectivity in these regions. * PTFCE-FDR<0.05. Abbreviations: CN, healthy controls; SCD, subjective cognitive decline; HIPe, hippocampal emotional region; HIPc, hippocampal cognitive region; HIPp, hippocampal perceptual region; TFCE, threshold-free cluster enhancement; FDR, false discovery rate; ITV, Intracranial volume; FD, framewise displacement; CEREpos.R, right cerebellum posterior lobe; FusG.L, left fusiform gyrus; PHG.L, l gyrus; IFGorb.R, right inferior frontal gyrus, orbital part; MTG.R, right middle temporal gyrus; MTG.L, left middle temporal gyrus; MFG.L, left medial frontal gyrus; PreCUN.L, left precuneus.