Research Paper Volume 13, Issue 2 pp 2727—2749

Melatonin protects against oxybenzone-induced deterioration of mouse oocytes during maturation

Effects of 10-7 mol/L melatonin with or without 500 nmol/L oxybenzone on gene expression in matured mouse oocytes. (A) Histone H3K4me3 demethylation-related genes (Kdm5a, Kdm5b, and Kdm5c). (B) Antioxidative stress genes (SOD and GPx1). (C) Anti-apoptosis gene Bcl2. (D) Pro-apoptosis genes (Bax, Caspase-3, and P53). Within each category, groups marked with different superscripted letters are significantly different (P

Figure 3. Effects of 10-7 mol/L melatonin with or without 500 nmol/L oxybenzone on gene expression in matured mouse oocytes. (A) Histone H3K4me3 demethylation-related genes (Kdm5a, Kdm5b, and Kdm5c). (B) Antioxidative stress genes (SOD and GPx1). (C) Anti-apoptosis gene Bcl2. (D) Pro-apoptosis genes (Bax, Caspase-3, and P53). Within each category, groups marked with different superscripted letters are significantly different (P < 0.05). The experiments were repeated three times, with n = 80-100 per group. Control, untreated control group; OBZ, oxybenzone-exposed group; OBZ+MT, “oxybenzone + melatonin” treatment group.