Research Paper Volume 13, Issue 2 pp 2750—2767

ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

The retinal structures in Alda1-treated aged mice. (A) A typical marked OCT image; (B) The thickness of the total retina; (C) The thickness of the ELM+IS/OS. (D) A typical marked HE staining image; (E) The number of ONL cell layers; (F) The number of INL cell layers. All analyses were performed in duplicate. Scale bar: 50 μm. Yellow box showed retinal structure analysis area. Values are presented as the mean ± SD, n = 6 mice per group. *Pvs young (WT); #Pvs aged (WT).

Figure 6. The retinal structures in Alda1-treated aged mice. (A) A typical marked OCT image; (B) The thickness of the total retina; (C) The thickness of the ELM+IS/OS. (D) A typical marked HE staining image; (E) The number of ONL cell layers; (F) The number of INL cell layers. All analyses were performed in duplicate. Scale bar: 50 μm. Yellow box showed retinal structure analysis area. Values are presented as the mean ± SD, n = 6 mice per group. *P<0.05: aged (WT) and aged (ALDH2+) vs young (WT); #P<0.05: aged (ALDH2+) vs aged (WT).