ALDH2 protects naturally aged mouse retina <i>via</i> inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

Pan Long; Mengshan He; Weiming Yan; Wei Chen; Dongyu Wei; Siwang Wang; Zuoming Zhang; Wei Ge; Tao Chen

doi:doi:10.18632/aging.202325

← Back

Research Paper Volume 13, Issue 2 pp 2750—2767

ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum

Figure 6. The retinal structures in Alda1-treated aged mice. (A) A typical marked OCT image; (B) The thickness of the total retina; (C) The thickness of the ELM+IS/OS. (D) A typical marked HE staining image; (E) The number of ONL cell layers; (F) The number of INL cell layers. All analyses were performed in duplicate. Scale bar: 50 μm. Yellow box showed retinal structure analysis area. Values are presented as the mean ± SD, n = 6 mice per group. *P<0.05: aged (WT) and aged (ALDH2+) vs young (WT); ^#P<0.05: aged (ALDH2+) vs aged (WT).